Standard Type Research Articles

Assessing the potential impact of assimilating total surface current velocities in the Met Office’s global ocean forecasting system

Accurate prediction of ocean surface currents is important for marine safety, ship routing, tracking of pollutants and in coupled forecasting. Presently, velocity observations are not routinely assimilated in global ocean forecasting systems, largely due to the sparsity of the observation network. Several satellite missions are now being proposed with the capability to measure Total Surface Current Velocities (TSCV). If successful, these would substantially increase the coverage of ocean current observations and could improve accuracy of ocean current forecasts through data assimilation. In this paper, Observing System Simulation Experiments (OSSEs) are used to assess the impact of assimilating TSCV in the Met Office’s global ocean forecasting system. Synthetic observations are generated from a high-resolution model run for all standard observation types (sea surface temperature, profiles of temperature and salinity, sea level anomaly and sea ice concentration) as well as TSCV observations from a Sea surface KInematics Multiscale monitoring (SKIM) like satellite. The assimilation of SKIM like TSCV observations is tested over an 11 month period. Preliminary experiments assimilating idealised single TSCV observations demonstrate that ageostrophic velocity corrections are not well retained in the model. We propose a method for improving ageostrophic currents through TSCV assimilation by initialising Near Inertial Oscillations with a rotated incremental analysis update (IAU) scheme. The OSSEs show that TSCV assimilation has the potential to significantly improve the prediction of velocities, particularly in the Western Boundary Currents, Antarctic Circumpolar Current and in the near surface equatorial currents. For global surface velocity the analysis root-mean-square-errors (RMSEs) are reduced by 23% and there is a 4-day gain in forecast RMSE. There are some degradations to the subsurface in the tropics, generally in regions with complex vertical salinity structures. However, outside of the tropics, improvements are seen to velocities throughout the water column. Globally there are also improvements to temperature and sea surface height when TSCV are assimilated. The TSCV assimilation largely corrects the geostrophic ocean currents, but results using the rotated IAU method show that the energy at inertial frequencies can be improved with this method. Overall, the experiments demonstrate significant potential benefit of assimilating TSCV observations in a global ocean forecasting system.

Gradually Typed Languages Should Be Vigilant!

In gradual typing, different languages perform different dynamic type checks for the same program even though the languages have the same static type system. This raises the question of whether, given a gradually typed language, the combination of the translation that injects checks in well-typed terms and the dynamic semantics that determines their behavior sufficiently enforce the static type system of the language. Neither type soundness, nor complete monitoring, nor any other meta-theoretic property of gradually typed languages to date provides a satisfying answer. In response, we present vigilance, a semantic analytical instrument that defines when the check-injecting translation and dynamic semantics of a gradually typed language are adequate for its static type system. Technically, vigilance asks if a given translation-and-semantics combination enforces the complete run-time typing history of a value, which consists of all of the types associated with the value. We show that the standard combination for so-called Natural gradual typing is vigilant for the standard simple type system, but the standard combination for Transient gradual typing is not. At the same time, the standard combination for Transient is vigilant for a tag type system but the standard combination for Natural is not. Hence, we clarify the comparative type-level reasoning power between the two most studied approaches to sound gradual typing. Furthermore, as an exercise that demonstrates how vigilance can guide design, we introduce and examine a new theoretical static gradual type system, dubbed truer, that is stronger than tag typing and more faithfully reflects the type-level reasoning power that the dynamic semantics of Transient gradual typing can guarantee.

Functional Ownership through Fractional Uniqueness

Ownership and borrowing systems, designed to enforce safe memory management without the need for garbage collection, have been brought to the fore by the Rust programming language. Rust also aims to bring some guarantees offered by functional programming into the realm of performant systems code, but the type system is largely separate from the ownership model, with type and borrow checking happening in separate compilation phases. Recent models such as RustBelt and Oxide aim to formalise Rust in depth, but there is less focus on integrating the basic ideas into more traditional type systems. An approach designed to expose an essential core for ownership and borrowing would open the door for functional languages to borrow concepts found in Rust and other ownership frameworks, so that more programmers can enjoy their benefits. One strategy for managing memory in a functional setting is through uniqueness types, but these offer a coarse-grained view: either a value has exactly one reference, and can be mutated safely, or it cannot, since other references may exist. Recent work demonstrates that linear and uniqueness types can be combined in a single system to offer restrictions on program behaviour and guarantees about memory usage. We develop this connection further, showing that just as graded type systems like those of Granule and Idris generalise linearity, a Rust-like ownership model arises as a graded generalisation of uniqueness. We combine fractional permissions with grading to give the first account of ownership and borrowing that smoothly integrates into a standard type system alongside linearity and graded types, and extend Granule accordingly with these ideas.

Perancangan Homestay Moni Kecamatan Kelimutu Kabupaten Ende (Tema Arsitektur Neo Vernakuler)

ABSTRACT   DOMINGGUS PITERSON BABO 2018320320. Moni Homestay Design, Kelimutu District, Ende Regency (Neo Vernacular Architecture Theme). Faculty of Engineering, University of Flores, Ende, 2023.. Mobile Number : 081339344579, E-mail : babosoni@gmail.com supervisor I : Ir. Dian Fitriawati Mochdar, ST., MT. supervisor II : Fabiola T.A, Kerong. ST., MT. Moni Kelimutu tourist destinations include culinary tourism, shopping tourism, and recreational tourism. This has a positive impact because the number of tourists coming is increasing. Therefore Homestay lodging is a very important element to support the existing potential. Homestay has an important role to introduce the character of each region. Ende Regency is one of the districts with many tribes and precisely in the Kelimutu sub-district, the local community highly respects customs and habits, so Moni's homestay is designed with the Neo Vernacular theme which aims to strengthen the identity and character of the local indigenous tribes. The application of this theme is dominated by wood elements as an aesthetic element of the building both in the facade of the building and in the atmosphere of the building space. Wood is the main material for building traditional Lio houses. So that the Homestay is designed to have the feel of the local environment so that people who stay at this Homestay feel the character of the local area. The methods used in this planning and design are 1). data collection methods include primary data (observation, documentation and interviews) and secondary data (literature studies and comparative studies); 2). The analysis method explains each analysis which contains field data, design criteria (theory), alternative analysis (alternative 1 and alternative 2), and responses (alternative selection). Analysis methods include analysis of design objects; site analysis; functional analysis (space organization, namely the organizational structure of actors, analysis of activities and space requirements (analysis of actors and actors' activities), room analysis (conditions, circulation, organization, relationships, size and zoning of space), shape analysis and analysis of building mass placement patterns; analysis building systems (structure and utilities); as well as analysis of regional regulations. 3). The design method includes design ideas and design concepts, namely the concept of neo vernacular architecture. The results obtained from designing Moni's homestay are based on a neo vernacular architectural approach which emphasizes more on building materials and site processing. The facilities built include the main facilities in the form of accommodation (suite room and standard type homestay), management building, as well as supporting facilities in the form of a cafeteria, photo spot, outdoor room and service area, parking. Keywords: Tourism, Homestay, Neo Vernacular Architecture

Unveiling the Anatomical and Functional Attributes of Stipular Colleters in Palicourea tetraphylla Cham. & Schltdl. and Palicourea rudgeoides (Müll. Arg.) Standl. (Rubiaceae)

The characterization of colleters in Rubiaceae is crucial for understanding their role in plant function. Analyzing colleters in Palicourea tetraphylla and Palicourea rudgeoides aims to deepen the understanding of these structures morphoanatomical and functional characteristics. The study reveals colleters with palisade epidermis and a parenchymatic central axis, classified as standard type, featuring vascularization and crystals. Colleter secretion, abundant in acidic mucopolysaccharides, proteins, and phenolic compounds, protects against desiccation. The ontogenesis, development, and senescence of the colleters are quite rapid and fulfill their role well in biotic and abiotic protection because these structures are present at different stages of development in the same stipule. Pronounced protrusions on the colleters surface, coupled with the accumulation of secretion in the intercellular and subcuticular spaces, suggest that the secretory process occurs through the wall, driven by pressure resulting from the accumulation of secretion. The microorganisms in the colleters’ secretion, especially in microbiota-rich environments such as the Atlantic Forest, provide valuable information about plant–microorganism interactions, such as resistance to other pathogens and organisms and ecological balance. This enhanced understanding of colleters contributes to the role of these structures in the plant and enriches knowledge about biological interactions within specific ecosystems and the family taxonomy.

Molecular characterization of clinical and environmental isolates from the Cryptococcus neoformans/C. Gattii species complexes of Maceió, Alagoas, Brazil.

Cryptococcosis is one of the major life-threatening opportunistic/systemic fungal diseases of worldwide occurrence, which can be asymptomatic or establish pneumonia and meningoencephalitis mainly in immunosuppressed patients, caused by the Cryptococcus neoformans and C. gattii species complexes. Acquisition is by inhaling fungal propagules from avian droppings, tree hollows and decaying wood, and the association of the molecular types with geographic origin, virulence and antifungal resistance have epidemiological importance. Since data on cryptococcosis in Alagoas are limited, we sought to determine the molecular types of etiological agents collected from clinical and environmental sources. We evaluated 21 isolates previously collected from cerebrospinal fluid and from environment sources (pigeon droppings and tree hollows) in Maceió-Alagoas (Brazil). Restriction fragment length polymorphism of URA5 gene was performed to characterize among the eight standard molecular types (VNI-VNIV and VGI-VGIV). Among isolates, 66.67% (14) were assigned to C. neoformans VNI - 12 of them (12/14) recovered from liquor and 2 from a tree hollow (2/14). One isolate from pigeon droppings (4.76%) corresponded to C. neoformans VNIV, while five strains from tree hollows and one from pigeon droppings (6, 28.57%) to C. gattii VGII. VNI-type was present in clinical and environmental samples and most C. neoformans infections were observed in HIV-positive patients, while types VNIV and VGII were prevalent in environmental sources in Alagoas. This is the first molecular characterization of Cryptococcus spp. in Alagoas, our study provides additional information on the ecoepidemiology of Cryptococcus spp. in Brazil, contributing to a closer view of the endemic species.

[Patient-specific cutting guides in corrective osteotomy near to the knee joint].

Patient-specific cutting guides (PSCG) are used in osteotomy near to the knee joint to simplify the operative technique, shorten the duration of surgery, reduce radiation exposure and to exactly realize the preoperative planning during surgery, especially when complex deformities are corrected simultaneously in multiple planes. The application of PSCG is in principle possible in all osteotomies near to the knee joint but is especially useful in multidimensional, complex osteotomy. No specific contraindications. After multidimensional 3D analysis and planning using apreoperative computed tomography (CT) protocol, a3D-printed patient-specific cutting guide is produced. This PSCG is used during standard osteotomy near to the knee. Using this PSCG the guided sawcut and predrilling of the screw positions inside the bone for the screws of the planned angle stable osteotomy plate are performed. The amount of the deformity correction needed is "stored" in the PSCG and is converted to the bony geometry during placement of the screws in the predrilled holes through the plate after opening or closing the osteotomy. Apart from that, the surgical approach and technique are equivalent to the standard osteotomy types near to the knee. The application of PSCG in osteotomy near to the knee does not change the postoperative management of the specific osteotomy. The use of patient-specific cutting guides leads to a higher accuracy in the implementation of the preoperative planning and the desired target axis is achieved with greater accuracy. Multidimensional complex corrections can also be exactly planned and implemented. In addition, the intraoperative radiation exposure for the operation team can possibly be reduced.

GEOGRAPHICAL INDICATORS

Geographical indicators play a crucial role in helping us navigate and identify locations in our daily lives. From road indicators guiding us to our destination to topographic symbols on maps helping us visualize the landscape, these indicators are essential for orientation and navigation. In this article, we will explore the different types of geographical indicators, the regulations and standards that govern them, as well as the challenges and solutions in maintaining and updating them. By understanding the importance of geographical indicators and the efforts involved in their upkeep, we can better appreciate their indicatorificance in our modern world.

The Effect of Welding Process Parameters on the nilon-6 Plate Friction Stir Welded Joint

Nylon-6 is one of the most extensively used engineering thermoplastics. Due to its durability, reduced weight, low coefficient of friction, and abrasion resistance, this polymer is an excellent substitute for various materials, including metals and rubber. Despite being those, nylon-6 materials are joined together utilizing multiple welding processes. The current work examined the viability of the friction stir welding (FSW) method on nylon 6 plates that were 4 mm thick to investigate the effect of tool diameter ratio and feed rate on nylon-6 sheets with the FSW method on the tensile properties of the joints. The 4 mm thickness of the nylon-6 plate was cut into the dimensions of 115 mm x 100 mm. The sliced plates were then joined through the FSW process using ST80-based tools with various parameters in the shoulder to pin diameter ratio (D/r ratio) of 10/3, 15/3, and 20/3 and feed rates (FR) of 4 mm/minute, 6 mm/minute, and 8 mm/minute at a rotational speed (RS) of 5800 RPM. Afterward, the weld joint is cut using water jet cutting according to the tensile testing standard ASTM D638 type IV. Following this, characterization of the speci-mens, including macrograph examination, hardness testing, and tensile testing, was carried out. The results show that the highest tensile strength was obtained at a tool diameter ratio of 10/3 mm with a feed rate of 6 mm/minute, with a tensile strength value of 19 MPa reaching up to circa 90% of joint efficiency. The strength of the welded joint then decreases as the diameter ratio of the tool increases with each feed rate. Some defects appeared at the higher tool diameter ratios welded joint, including incomplete fusion, flash, thinning, and lack of bonding. In conclusision the combination of a D/d ratio of 10/3 and a FR of 6 mm/min at RS 5800 RPM can provide the optimal conditions for a strong nylon-6 friction stir welded joint.

Constraining dark energy cosmologies with spatial curvature using Supernovae JWST forecasting

Recent cosmological tensions, in particular, to infer the local value of the Hubble constant H 0, have developed new independent techniques to constrain cosmological parameters in several cosmologies. Moreover, even when the concordance Cosmological Constant Cold Dark Matter (ΛCDM) model has been well constrained with local observables, its physics has shown deviations from a flat background. Therefore, to explore a possible deviation from a flat ΛCDM model that could explain the H 0 value in tension with other techniques, in this paper we study new cosmological constraints in spatial curvature dark energy models. Additionally, to standard current Supernovae Type Ia (SNIa) catalogs, we extend the empirical distance ladder method through an SNIa sample using the capabilities of the James Webb Space Telescope (JWST) to forecast SNIa up to z ∼ 6, with information on the star formation rates at high redshift. Furthermore, we found that our constraints provide an improvement in the statistics associated with Ω m when combining SNIa Pantheon and SNIa Pantheon+ catalogs with JW forecasting data.

Geotechnical case study of fine-grained transition soils in landslides: anomalous behavior in San Cayetano Formation (Loja, Ecuador)

Numerous landslides, either natural or produced by excavations in road works, occur in the intramontane Neogene Loja basin (southern Ecuadorian Andes) and can be associated with the clayey silts, low plasticity soils (ML). Thirty-two undisturbed samples from eight sites were tested in laboratory to characterize the stress-strain geotechnical soil response, showing a higher internal friction angle and higher cohesion with respect to the standard ML soil values. A testing profile of a road constructed with these soils has been modelled using finite element methods to calculate both the safety factor and the mechanism of evolution. Anomalous behaviour is evidenced when a standard ML soil type is considered in the model, with a higher security factor than the less stable and more susceptible ML soils of Loja basin. Therefore, this contribution may serve as a warning to designers and engineers when constructing new structures on these soils. Additionally, it enables the identification of the most effective test for assessing high susceptibility in ML soils, contributing to the refinement and enhancement of methodological procedures during project execution.

Late Mesozoic–Cenozoic geoheritage resources of the Kharga Oasis (Egypt): Novel assessment, exploitation perspectives, and policy implications

Geoheritage resources are valuable to countries and regions, which make urgent their exploration. Particularly, Egyptian geoheritage has been examined only partly, and it has not been reported from many areas. New field investigations in the Kharga Oasis in the southern Western Desert of Egypt permit to report a new portion of geoheritage resources. The collected materials are used to propose six geosites, describe them (particularly, standardized geoheritage types are established), and assess semi-quantitatively. The approach is the same as already used for some other areas of Egypt, and the semi-quantitative assessment is based on scoring of various geosite properties with the different weight. It is established that these geosites exhibit lithologies and depositional environments of Upper Cretaceous–Eocene terrestrial and marine sedimentary rocks, Quaternary terrestrial carbonates (tufa deposits), and residual desert landforms. The geosites are attributed to the sedimentary, palaeogeographical, stratigraphical, palaeontological, and geomorphological geoheritage types. Scoring them by several criteria implies that two geosites (Naqb El-Rufuf and Naqb Bulaq) are national and four geosites (Naqb Assiut, Wadi El-Midawara, Gebel Taref, and Kharga Stadium) are regional in rank. The accessibility of some geosites is limited, and the Kharga Stadium geosite demonstrates significant vulnerability due to its location in the urban area. Generally, the analyses imply the presence of a valuable geoheritage resource in the Kharga Oasis. The outcomes of the present study also indicate the perspectives of scientific, educational, and touristic exploitation of the established geoheritage resources and the need in the development of the optimal policy for their effective management. Geopark creation seems to be a plausible instrument for the implementation of this policy, and its proposal requires further investigations of geological and cultural heritage of the Kharga Oasis.

Selection of Catechin Biosynthesis-Related Genes and Functional Analysis from Chromosome-Level Genome Assembly in C. sinensis L. Variety 'Sangmok'.

Camellia is an important plant genus that includes well-known species such as C. sinensis, C. oleifera, and C. japonica. The C. sinensis cultivar 'Sangmok', one of Korea's standard types of tea landraces, is a small evergreen tree or shrub. Genome annotation has shown that Korean tea plants have special and unique benefits and superior components, such as catechin. The genome of Camellia sinensis cultivar 'Sangmok' was assembled on the chromosome level, with a length of 2678.62 Mbp and GC content of 38.16%. Further, 15 chromosome-scale scaffolds comprising 82.43% of the assembly (BUSCO completeness, 94.3%) were identified. Analysis of 68,151 protein-coding genes showed an average of 5.003 exons per gene. Among 82,481 coding sequences, the majority (99.06%) were annotated by Uniprot/Swiss-Prot. Further analysis revealed that 'Sangmok' is closely related to C. sinensis, with a divergence time of 60 million years ago. A total of 3336 exclusive gene families in 'Sangmok' were revealed by gene ontology analysis to play roles in auxin transport and cellular response mechanisms. By comparing these exclusive genes with 551 similar catechin genes, 17 'Sangmok'-specific catechin genes were identified by qRT-PCR, including those involved in phytoalexin biosynthesis and related to cytochrome P450. The 'Sangmok' genome exhibited distinctive genes compared to those of related species. This comprehensive genomic investigation enhances our understanding of the genetic architecture of 'Sangmok' and its specialized functions. The findings contribute valuable insights into the evolutionary and functional aspects of this plant species.

Abstract 7393: Tumor model to tumor treatment: Applying deep learning approaches to map multimodal data from cancer model systems to patients

Abstract Despite large-scale efforts to measure the effect of drug screens in cancer cell lines, mapping the effects of drugs to patient samples has been a challenge. Biological differences between cell lines and patients, such as lack of immune system or microbiome, in-vitro survival adaptations, and biases in measurement technologies create differences across sample modalities that can confound analysis including prediction with machine learning. In this work, we propose a multiway batch correction strategy to enable algorithmic prediction of tumor drug response across model systems and patient data.Recent advances in batch correction algorithms have been motivated by the need to correct for batch effects in single-cell omics and include diverse approaches such as variational autoencoders (VAEs) and generative adversarial networks (GANs). Given the successes of these generative deep learning methods in single cell sequencing analysis, we worked to employ similar approaches to correct large omics measurements across various cancer datasets. Here, we describe mapping of datasets from diverse data sources and model systems to the same space, so that a predictive model of drug response built in a system such as cell lines can be used in biologically relevant models such as organoids, patient derived xenografts, and tumor data. Specifically, we introduce a modified loss function in a VAE using cosine similarity distance to minimize the effect of different cancer model systems in predicting cancer types. We evaluate the method on standard data types for drug response prediction - gene expression, copy number variation, and protein abundance. For this method, the cosine similarity is added as an additional term to the VAE reconstruction and Kullback-Leibler divergence loss terms. This injects a quantification of the dissimilarity between the tumor and tumor model distributions into the backpropagation and gradient descent for updating the model parameters resulting in an encoded representation of the data where the effect of data source has been attenuated while preserving the phenotypic signal. We evaluate our approach for biological signal preservation while reducing model system-specific noise with logistic regression and Euclidean distance. Our results show that the proposed VAE can effectively correct for platform effects and improve the accuracy of downstream integrative analyses. This study has the potential to improve the accuracy and translatability of proteogenomic drug response studies. The proposed modified VAE could be used to correct for platform effects in a variety of datasets, including those from different studies, different platforms, and different cancer types. This could lead to new insights into cancer biology, calibration of cancer patient digital twins, and the development of new diagnostic and therapeutic strategies. Citation Format: Brian Karlberg, Raphael Kirchgaessner, Jeremy R. Jacobson, Kyle Ellrott, Sara J. Gosline. Tumor model to tumor treatment: Applying deep learning approaches to map multimodal data from cancer model systems to patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7393.

Type Label Framework for Bonded Force Fields in LAMMPS.

New functionality is added to the LAMMPS molecular simulation package, which increases the versatility with which LAMMPS can interface with supporting software and manipulate information associated with bonded force fields. We introduce the "type label" framework that allows atom types and their higher-order interactions (bonds, angles, dihedrals, and impropers) to be represented in terms of the standard atom type strings of a bonded force field. Type labels increase the human readability of input files, enable bonded force fields to be supported by the OpenKIM repository, simplify the creation of reaction templates for the REACTER protocol, and increase compatibility with external visualization tools, such as VMD and OVITO. An introductory primer on the forms and use of bonded force fields is provided to motivate this new functionality and serve as an entry point for LAMMPS and OpenKIM users unfamiliar with bonded force fields. The type label framework has the potential to streamline modeling workflows that use LAMMPS by increasing the portability of software, files, and scripts for preprocessing, running, and postprocessing a molecular simulation.

Design and Simulation of a Solar Powered House in Muğla: Roof Decorated with Half Cut Cells

In this article, the performance, design and efficiency calculation of photovoltaic systems were made using PvSol program. For roof type panel design close to standard installations, panel position and panel type were designed based on Muğla province sun hour data and roof shading factor. In this study, the data obtained for the roof type installation designed in Muğla city using monocrystalline, polycrystalline and half-cut monocrystalline cells were compared. When yield, area and price parameters were compared, it was found that the best cell type was half-section monocrystalline. As a result of the simulations, it was found that the average daily energy need of the house is 6.4kWh, fed by 14 half-section monocrystalline panels. The results obtained are consistent with the data in the literature.

Exploring diverse maintenance and repair standards in the container industry: a comparative analysis of criteria and practices

The maintenance and repair standards have always been a problem in the container industry. Due to different preferences of criterias of different parties caused many conflicts. This paper examines the different types of criterias and standards for general purpose containers, and different areas of use of these criterias.  The main reason of this paper is to be an explanatory element to define the differences of these criterias. The fundamental structural dimensional basis for an intermodal container is ISO container standards which defines the main structural features. Although it presents dimensional tolerances to a certain degree, it is nearly impossible to use these criterias for the operators and owners in day to day operations. As a result there have been various published maintenance and repair criterias, used by different parties partaking in the container industry. The different organizations and associations published standards suiting their own needs. Although there are lesser implemented criterias like Wind and Water Tight and Cargo Worth, the most known and most implemented criterias around the world are Unified Container Inspection and Repair Criteria, Common Interchange Criteria and IICL publications. While the Wind and Water Tight criteria is generally used for containers which are used as storage, the Cargo Worthy is used for the containers meet the minimum requirements for transport. The Unified Container Inspection Criteria is preferred by the shipping lines and operators, and the Common Interchange Criteria and IICL – 6 are preferred by lessors.

Profile likelihoods for parameters in trans-Gaussian geostatistical models

Profile likelihoods are rarely used in geostatistical models due to the computational burden imposed by repeated decompositions of large variance matrices. Accounting for uncertainty in covariance parameters can be highly consequential in geostatistical models as some covariance parameters are poorly identified, the problem is severe enough that the differentiability parameter of the Matern correlation function is typically treated as fixed. The problem is compounded with anisotropic spatial models as there are two additional parameters to consider. In this paper, we make the following contributions: Firstly, a methodology is created for profile likelihoods for Gaussian spatial models with Matérn family of correlation functions, including anisotropic models. This methodology adopts a novel reparameterization for generation of representative points, and uses GPUs for parallel profile likelihoods computation in software implementation. Then, we show the profile likelihood of the Matérn shape parameter is often quite flat but still identifiable, it can usually rule out very small values. Finally, simulation studies and applications on real data examples show that profile-based confidence intervals of covariance parameters and regression parameters have superior coverage to the traditional standard Wald type confidence intervals.

The Emerging Technology in Cybercrime of Cyberspace: An Overview

Cyber criminology and Cyberspace are closely related aspects; hence, Cyberspace provides an environment where Cyberspace occurs. Cyberspace is a domain that in the rapid increase in technology signifies how digital platforms are vulnerable for securing data and privacy of an individual, which causes various crimes in the world. Cyberspace is known as organized criminal attacks on Cybersecurity and Cyberspace through attacks, Hacking, Bullying, etc. Cybersecurity and information security are essential and unavoidable components of using the internet or digital places. Numerous types of standards, protocols, policies, technologies, and antiviruses have been developed to protect data and privacy. To ensure that technology is increasing as security, privacy, and data taken as a liability, which is the main cause of Cybercrime.

Genetic Diversity of Brucella melitensis Isolated from Domestic Ruminants in Iraq.

The control and eradication of brucellosis represents a critical objective for Veterinary and Health Authorities across several countries globally. Efficient surveillance programs play a pivotal role in detecting and managing outbreaks. Epidemiological investigations significantly benefit from standardized and efficient molecular typing techniques and analytical tools, enabling public health laboratories to identify the origin of outbreaks. This study aimed to sequence Brucella spp. strains isolated in Iraq from different ruminant species to verify their molecular epidemiological correlations and, above all, to shed a light on how these Iraqi isolates are positioned in the phylogenetic context of Brucella spp. The 35 isolates under study were from abortion, milk, placenta, and the fetal membranes of sheep, cattle, and buffalo. Genotyping involved various techniques: MLVA-16, Whole Genome Sequencing, MLST, and cgMLST. All the Iraqi isolates from our study clustered in MLVA-16 within the East Mediterranean clade, and all but one grouped together in the same branch of the MST tree. MST analysis showed the minimum distance of one allele between the studied isolates, except for one strain from buffalo, which was positioned farther away from the rest of the isolates. In cgMLST, the majority of strains grouped within a large cluster predominantly comprising genotypes from the Middle East. The application of different control measures in different territories based on molecular epidemiological studies would increase the chances of maximizing public health benefits and minimizing the spread of infection to disease-free or lower prevalence areas.